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Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.

12 rearranged human VH6 immunoglobulin heavy chain genes arising from the same rearrangement were isolated without preselection from the RNA of a fragment of human spleen. The 12 clones were isolated from a pool of 31 unique VH6 clones arising from 18 unique rearrangements. 2 of the 12 related clone...

Повний опис

Збережено в:
Бібліографічні деталі
Опубліковано в::J Clin Invest
Автори: Varade, W S, Insel, R A
Формат: Artigo
Мова:Inglês
Опубліковано: American Society for Clinical Investigation 1993
Предмети:
Онлайн доступ:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288167/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7682578/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116397
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