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Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.

The molecular defect in the abnormal fibrinogen Dusart (Paris V) that is associated with thrombophilia was determined by sequence analysis of genomic DNA that had been amplified using the polymerase chain reaction. The propositus was heterozygous for a single base change (C-->T) in the A alpha-chain...

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Udgivet i:J Clin Invest
Principais autores: Koopman, J, Haverkate, F, Grimbergen, J, Lord, S T, Mosesson, M W, DiOrio, J P, Siebenlist, K S, Legrand, C, Soria, J, Soria, C
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288141/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8473507/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116371
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