Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire.

Expression of Ig and Ig-related genes has been studied in bone marrow cells from two patients with severe form of X-linked agammaglobulinemia (XLA). Phenotypic analysis revealed the presence of pre-B cells, in the absence of mature B cell markers. The pre-B-specific genes, lambda-like and V pre-B, w...

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Pubblicato in:	J Clin Invest
Autori principali:	Milili, M, Le Deist, F, de Saint-Basile, G, Fischer, A, Fougereau, M, Schiff, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288139/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8473505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116369
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