Detecting low level sequence variantsin recombinant monoclonal antibodies

A systematic analytical approach combining tryptic and chymotryptic peptide mapping with a Mascot Error Tolerant Search (ETS) has been developed to detect and identify low level protein sequence variants, i.e., amino acid substitutions, in recombinant monoclonal antibodies. The reversed-phase HPLC s...

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Detalhes bibliográficos
Main Authors: Yang, Yi, Strahan, Alex, Li, Charlene, Shen, Amy, Liu, Hongbin, Ouyang, Jun, Katta, Viswanatham, Francissen, Kathleen, Zhang, Boyan
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881255/
https://ncbi.nlm.nih.gov/pubmed/20400866
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