Allosteric inhibition of human lymphoblast and purified porphobilinogen deaminase by protoporphyrinogen and coproporphyrinogen. A possible mechanism for the acute attack of variegate porphyria.
Variegate porphyria (VP) is characterized by photocutaneous lesions and acute neuropsychiatric attacks. Decreased protoporphyrinogen oxidase activity results in accumulation of protoporphyrin (ogen) IX and coproporphyrin (ogen) III. During acute attacks delta-aminolevulinic acid and porphobilinogen...
Furkejuvvon:
| Publikašuvnnas: | J Clin Invest |
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| Váldodahkkit: | , , |
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
American Society for Clinical Investigation
1993
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| Fáttát: | |
| Liŋkkat: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7682572/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116348 |
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