Alpha 2-antiplasmin supplementation inhibits tissue plasminogen activator-induced fibrinogenolysis and bleeding with little effect on thrombolysis.

Tissue plasminogen activator (t-PA) causes fibrinogen proteolysis when alpha 2-antiplasmin levels fall, and this may contribute to t-PA-induced hemorrhage. Because clot-bound plasmin is protected from alpha 2-antiplasmin inhibition, we tested the possibility that alpha 2-antiplasmin supplementation...

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Publié dans:	J Clin Invest
Auteurs principaux:	Weitz, J I, Leslie, B, Hirsh, J, Klement, P
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288105/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7682569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116335
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