Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

The effect of human eosinophil major basic protein (MBP) as well as other eosinophil proteins, on binding of [3H]N-methyl-scopolamine ([3H]NMS: 1 x 10(-10) M) to muscarinic M2 receptors in heart membranes and M3 receptors in submandibular gland membranes was studied. MBP inhibited specific binding o...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Jacoby, D B, Gleich, G J, Fryer, A D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8473484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116331
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