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Design, synthesis and preliminary in vitro and in vivo evaluation of 4-[(18)F]fluoro-N-(2-diethylaminoethyl)benzamide ([(18)F]-DAFBA): A novel potential PET probe to image melanoma tumors
In order to develop a PET radiopharmaceutical to image malignant melanoma, we synthesized N-(2-diethylaminoethyl)-4-[(18)F]fluorobenzamide ([(18)F]-DAFBA). In vitro studies show a high uptake of [(18)F]-DAFBA by the B16F1 melanoma cells. No significant binding was seen for DAFBA to the sigma-1 and s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880618/ https://ncbi.nlm.nih.gov/pubmed/19222206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc8005094 |
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