Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

β-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if β-amyloid contributes to intellectual disability in younger individuals. We used a γ-secretase inhibit...

Full description

Saved in:
Bibliographic Details
Main Authors: Netzer, William J., Powell, Craig, Nong, Yi, Blundell, Jacqueline, Wong, Lili, Duff, Karen, Flajolet, Marc, Greengard, Paul
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880593/
https://ncbi.nlm.nih.gov/pubmed/20532168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010943
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items