Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor Exploits Competition between L-Arginine Ligands and Resident Arginine Residues

An elegantly simple and probably ancient molecular mechanism of allostery is described for the Escherichia coli arginine repressor ArgR, the master feedback regulator of transcription in L-arginine metabolism. Molecular dynamics simulations with ArgRC, the hexameric domain that binds L-arginine with...

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Main Authors: Strawn, Rebecca, Melichercik, Milan, Green, Michael, Stockner, Thomas, Carey, Jannette, Ettrich, Rüdiger
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880562/
https://ncbi.nlm.nih.gov/pubmed/20532206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000801
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