The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors

[Image: see text] Deregulation of the phosphoinositide 3-kinase (PI3K) pathway has been implicated in numerous pathologies like cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small molecule and ATP-competitive PI3K inhibitors with a wide range of selectivities have entered...

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Autori principali: Berndt, Alex, Miller, Simon, Williams, Olusegun, Le, Daniel D., Houseman, Benjamin T., Pacold, Joseph I., Gorrec, Fabrice, Hon, Wai-Ching, Liu, Yi, Rommel, Christian, Gaillard, Pascale, Ruckle, Thomas, Schwarz, Matthias K., Shokat, Kevan M., Shaw, Jeffrey P., Williams, Roger L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880452/
https://ncbi.nlm.nih.gov/pubmed/20081827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.293
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