Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.

A single point mutation in the growth hormone (GH) receptor gene generating a Phe-->Ser substitution in the extracellular binding domain of the receptor has been identified in one family with Laron type dwarfism. The mutation was introduced by site-directed mutagenesis into cDNAs encoding the full-l...

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Publié dans:	J Clin Invest
Auteurs principaux:	Edery, M, Rozakis-Adcock, M, Goujon, L, Finidori, J, Lévi-Meyrueis, C, Paly, J, Djiane, J, Postel-Vinay, M C, Kelly, P A
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8450064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116304
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