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Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration

Little is known about which components of the axonal cytoskeleton might break during rapid mechanical deformation, such as occurs in traumatic brain injury. Here, we micropatterned neuronal cell cultures on silicone membranes to induce dynamic stretch exclusively of axon fascicles. After stretch, un...

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Detalhes bibliográficos
Main Authors: Tang-Schomer, Min D., Patel, Ankur R., Baas, Peter W., Smith, Douglas H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879950/
https://ncbi.nlm.nih.gov/pubmed/20019243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-142844
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