High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and β-cell apoptosis

Patients with type 2 diabetes lose β cells, but the underlying mechanisms are incompletely understood. Glucose-6-phosphate dehydrogenase (G6PD) is the principal source of the major intracellular reductant, NADPH, which is required by many enzymes, including enzymes of the antioxidant pathway. Previo...

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Main Authors: Zhang, Zhaoyun, Liew, Chong Wee, Handy, Diane E., Zhang, Yingyi, Leopold, Jane A., Hu, Ji, Guo, Lili, Kulkarni, Rohit N., Loscalzo, Joseph, Stanton, Robert C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Federation of American Societies for Experimental Biology 2010
Ábhair:
Research Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879949/
https://ncbi.nlm.nih.gov/pubmed/20032314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-136572
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