Direct Bacterial Killing In Vitro by Recombinant Nod2 Is Compromised by Crohn's Disease-Associated Mutations

BACKGROUND: A homeostatic relationship with the intestinal microflora is increasingly appreciated as essential for human health and wellbeing. Mutations in the leucine-rich repeat (LRR) domain of Nod2, a bacterial recognition protein, are associated with development of the inflammatory bowel disorde...

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Detalhes bibliográficos
Main Authors: Perez, Laurent-Herve, Butler, Matt, Creasey, Tammy, Dzink-Fox, JoAnn, Gounarides, John, Petit, Stephanie, Ropenga, Anna, Ryder, Neil, Smith, Kathryn, Smith, Philip, Parkinson, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879363/
https://ncbi.nlm.nih.gov/pubmed/20531959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010915
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