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Intracellular translocation of calmodulin and Ca(2+)/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes

We have recently shown that stimulation of cultured neonatal cardiomyocytes with endothelin-1 (ET-1) first produces conformational disorder within the ryanodine receptor (RyR2) and diastolic Ca(2+) leak from the sarcoplasmic reticulum (SR), then develops hypertrophy (HT) in the cardiomyocytes [Hamad...

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Detalhes bibliográficos
Main Authors: Gangopadhyay, Jaya Pal, Ikemoto, Noriaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878933/
https://ncbi.nlm.nih.gov/pubmed/20433809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.04.129
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