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Ribosomal protein S19 binds to its own mRNA with reduced affinity in Diamond-Blackfan Anemia

Heterozygous mutations in the ribosomal protein S19 (RPS19) gene are associated with Diamond-Blackfan anemia (DBA). The mechanism by which RPS19 mediates anemia are still unclear, as well as the regulation of RPS19 expression. We show herein that RPS19 binds specifically to the 5′ untranslated regio...

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Detalhes bibliográficos
Main Authors: Schuster, Jens, Fröjmark, Anne-Sophie, Nilsson, Per, Badhai, Jitendra, Virtanen, Anders, Dahl, Niklas
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878864/
https://ncbi.nlm.nih.gov/pubmed/20395159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2010.03.007
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