Comparative Activities of Nickel(II) and Zinc(II) Complexes of Asymmetric [NN'O] Ligands as 26S Proteasome Inhibitors

In this study, we compare the proteasome inhibition capabilities of two anticancer candidates, [Ni(L(IA))(2)] (1) and [Zn(L(IA))(2)] (2), where L(IA-) is the deprotonated form of the ligand 2,4-diiodo-6-(((2-pyridinylmethyl)amino)methyl)phenol. Species 1 contains nickel(II), a considerably inert ion...

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Hlavní autoři: Frezza, Michael, Hindo, Sarmad Sahiel, Tomco, Dajena, Allard, Marco, Cui, Qiuzhi Cindy, Heeg, Mary Jane, Chen, Di, Dou, Q. Ping, Verani, Claudio N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878368/
https://ncbi.nlm.nih.gov/pubmed/19496541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic900276g
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