Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon

BACKGROUND: MLL2, an epigenetic regulator in mammalian cells, mediates histone 3 lysine 4 tri-methylation (H3K4me3) through the formation of a multiprotein complex. MLL2 shares a high degree of structural similarity with MLL, which is frequently disrupted in leukemias via chromosomal translocations....

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Detalhes bibliográficos
Main Authors: Natarajan, Thanemozhi G, Kallakury, Bhaskar V, Sheehan, Christine E, Bartlett, Margaret B, Ganesan, Natarajan, Preet, Anju, Ross, Jeffrey S, FitzGerald, Kevin T
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Primary research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878298/
https://ncbi.nlm.nih.gov/pubmed/20433758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-10-13
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