Small Molecular Compounds Inhibit HIV-1 Replication through Specifically Stabilizing APOBEC3G

APOBEC3G (hA3G) is a host inhibitor for human immunodeficiency virus, type 1 (HIV-1). However, HIV-1 Vif binds hA3G and induces its degradation. We have established a screening system to discover inhibitors that protect hA3G from Vif-mediated degradation. Through screening, compounds IMB-26 and IMB-...

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Detalhes bibliográficos
Main Authors: Cen, Shan, Peng, Zong-Gen, Li, Xiao-Yu, Li, Zhuo-Rong, Ma, Jing, Wang, Yue-Ming, Fan, Bo, You, Xue-Fu, Wang, Yu-Ping, Liu, Fei, Shao, Rong-Guang, Zhao, Li-Xun, Yu, Liyan, Jiang, Jian-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878088/
https://ncbi.nlm.nih.gov/pubmed/20363737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085308
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