Stacked Sets of Parallel, In-register β-Strands of β(2)-Microglobulin in Amyloid Fibrils Revealed by Site-directed Spin Labeling and Chemical Labeling

β(2)-microglobulin (β(2)m) is a 99-residue protein with an immunoglobulin fold that forms β-sheet-rich amyloid fibrils in dialysis-related amyloidosis. Here the environment and accessibility of side chains within amyloid fibrils formed in vitro from β(2)m with a long straight morphology are probed b...

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Bibliographic Details
Main Authors: Ladner, Carol L., Chen, Min, Smith, David P., Platt, Geoffrey W., Radford, Sheena E., Langen, Ralf
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878032/
https://ncbi.nlm.nih.gov/pubmed/20335170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.117234
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