In Situ trans Ligands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics

CD22, a regulator of B-cell signaling, is a siglec that recognizes the sequence NeuAcα2–6Gal on glycoprotein glycans as ligands. CD22 interactions with glycoproteins on the same cell (in cis) and apposing cells (in trans) modulate its activity in B-cell receptor signaling. Although CD22 predominantl...

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Main Authors: Ramya, T. N. C., Weerapana, Eranthie, Liao, Lujian, Zeng, Ying, Tateno, Hiroaki, Liao, Liang, Yates, John R., Cravatt, Benjamin F., Paulson, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877991/
https://ncbi.nlm.nih.gov/pubmed/20172905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900461-MCP200
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