Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3(+/–) mice with a diet low in calcium and vitamin...

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Detalhes bibliográficos
Main Authors: Grigorieva, Irina V., Mirczuk, Samantha, Gaynor, Katherine U., Nesbit, M. Andrew, Grigorieva, Elena F., Wei, Qiaozhi, Ali, Asif, Fairclough, Rebecca J., Stacey, Joanna M., Stechman, Michael J., Mihai, Radu, Kurek, Dorota, Fraser, William D., Hough, Tertius, Condie, Brian G., Manley, Nancy, Grosveld, Frank, Thakker, Rajesh V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877956/
https://ncbi.nlm.nih.gov/pubmed/20484821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42021
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