IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis

Enteropathy-associated T cell lymphoma is a severe complication of celiac disease (CD). One mechanism suggested to underlie its development is chronic exposure of intraepithelial lymphocytes (IELs) to potent antiapoptotic signals initiated by IL-15, a cytokine overexpressed in the enterocytes of ind...

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Главные авторы: Malamut, Georgia, El Machhour, Raja, Montcuquet, Nicolas, Martin-Lannerée, Séverine, Dusanter-Fourt, Isabelle, Verkarre, Virginie, Mention, Jean-Jacques, Rahmi, Gabriel, Kiyono, Hiroshi, Butz, Eric A., Brousse, Nicole, Cellier, Christophe, Cerf-Bensussan, Nadine, Meresse, Bertrand
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2010
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877946/
https://ncbi.nlm.nih.gov/pubmed/20440074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41344
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