Type-I IFN Signaling Suppresses an Excessive IFN-γ Response and Thus Prevents Lung Damage and Chronic Inflammation During Pneumocystis (PC) Clearance in CD4 T Cell-Competent Mice

Immune-reconstitution after highly active antiretroviral therapy (HAART) is often incomplete, and some HIV-infected individuals fail to regenerate type-I interferon (IFN)–producing pDCs. We recently demonstrated that during Pneumocystis (PC) infection in CD4 T cell–competent mice the absence of type...

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Detalhes bibliográficos
Main Authors: Meissner, Nicole, Swain, Steve, McInnerney, Kate, Han, Soo, Harmsen, Allen G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877842/
https://ncbi.nlm.nih.gov/pubmed/20395428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091158
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