HIV and SIV Induce Alterations in CNS CaMKII Expression and Activation : A Potential Mechanism for Cognitive Impairment

The molecular mechanisms underlying learning and memory impairment in patients with HIV-associated neurological disease have remained unclear. Calcium/calmodulin-dependent kinase II (CaMKII) has key roles in synaptic potentiation and memory storage in neurons and also may have immunomodulatory funct...

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Main Authors: Gupta, Ravi G., Kelly, Kathleen M., Helke, Kris L., Queen, Suzanne E., Karper, Jami M., Dorsey, Jamie L., Brice, Angela K., Adams, Robert J., Tarwater, Patrick M., Kolson, Dennis L., Mankowski, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877839/
https://ncbi.nlm.nih.gov/pubmed/20382699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090809
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