Hepatic Fibrosis Is Enhanced and Accompanied by Robust Oval Cell Activation after Chronic Carbon Tetrachloride Administration to Egr-1-Deficient Mice

The transcription factor early growth response (Egr)−1 regulates the expression of genes required for execution of the wound healing response. Multiple cycles of injury, coupled to incomplete wound healing, lead to fibrosis. Therefore, we hypothesized that Egr-1 is required for the development of he...

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Bibliographic Details
Main Authors: Pritchard, Michele T., Nagy, Laura E.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
Subjects:
Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877836/
https://ncbi.nlm.nih.gov/pubmed/20395449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091186
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