Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction

RATIONALE: Transient Receptor Potential Melastatin-3 (TRPM3) is a calcium-permeable ion channel activated by the neurosteroid pregnenolone sulphate and positively coupled to insulin secretion in β-cells. Although vascular TRPM3 mRNA has been reported, there is no knowledge of TRPM3 protein or its re...

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Autori principali: Naylor, Jacqueline, Li, Jing, Milligan, Carol J, Zeng, Fanning, Sukumar, Piruthivi, Hou, Bing, Sedo, Alicia, Yuldasheva, Nadira, Majeed, Yasser, Beri, Dhananjay, Jiang, Shan, Seymour, Victoria AL, McKeown, Lynn, Kumar, Bhaskar, Harteneck, Christian, O’Regan, David, Wheatcroft, Stephen B, Kearney, Mark T, Jones, Clare, Porter, Karen E, Beech, David J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877666/
https://ncbi.nlm.nih.gov/pubmed/20360246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.219329
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