Viral apoptosis is induced by IRF-3-mediated activation of Bax

Upon infection with many RNA viruses, the cytoplasmic retinoic acid inducible gene-I (RIG-I) pathway activates the latent transcription factor IRF-3, causing its nuclear translocation and the induction of many antiviral genes, including those encoding interferons. Here, we report a novel and distinc...

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Main Authors: Chattopadhyay, Saurabh, Marques, Joao T, Yamashita, Michifumi, Peters, Kristi L, Smith, Kevin, Desai, Avanti, Williams, Bryan R G, Sen, Ganes C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876960/
https://ncbi.nlm.nih.gov/pubmed/20360684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.50
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