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N-acetylglutamate synthase: structure, function and defects

N-acetylglutamate (NAG) is a unique enzyme cofactor, essential for liver ureagenesis in mammals while it is the first committed substrate for de novo arginine biosynthesis in microorganisms and plants. The enzyme that produces NAG from glutamate and CoA, NAG synthase (NAGS), is allosterically inhibi...

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Autors principals: Caldovic, Ljubica, Mew, Nicholas Ah, Shi, Dashuang, Morizono, Hiroki, Yudkoff, Marc, Tuchman, Mendel
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876818/
https://ncbi.nlm.nih.gov/pubmed/20303810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2010.02.018
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