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Snf1 Promotes Phosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2 by Activating Gcn2 and Inhibiting Phosphatases Glc7 and Sit4

Snf1 is the ortholog of mammalian AMP-activated kinase and is responsible for activation of glucose-repressed genes at low glucose levels in budding yeast. We show that Snf1 promotes the formation of phosphorylated α subunit of eukaryotic translation initiation factor 2 (eIF2α-P), a regulator of gen...

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Detalhes bibliográficos
Main Authors: Cherkasova, Vera, Qiu, Hongfang, Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876683/
https://ncbi.nlm.nih.gov/pubmed/20404097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00183-10
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