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Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1
Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due to malnutrition caused by severe hyperkeratosis of the upper digestive tract. Analysis of Keap1::Nrf2 double mutant mi...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2876677/ https://ncbi.nlm.nih.gov/pubmed/20404090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01591-09 |
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