Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies

Cell culture-adaptive mutations within the hepatitis C virus (HCV) E2 glycoprotein have been widely reported. We identify here a single mutation (N415D) in E2 that arose during long-term passaging of HCV strain JFH1-infected cells. This mutation was located within E2 residues 412 to 423, a highly co...

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Auteurs principaux: Dhillon, Simrat, Witteveldt, Jeroen, Gatherer, Derek, Owsianka, Ania M., Zeisel, Mirjam B., Zahid, Muhammad N., Rychłowska, Małgorzata, Foung, Steven K. H., Baumert, Thomas F., Angus, Allan G. N., Patel, Arvind H.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876616/
https://ncbi.nlm.nih.gov/pubmed/20237087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02153-09
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