RSK-Mediated Phosphorylation in the C/EBPβ Leucine Zipper Regulates DNA Binding, Dimerization, and Growth Arrest Activity

The bZIP transcription factor C/EBPβ is a target of Ras signaling that has been implicated in Ras-induced transformation and oncogene-induced senescence (OIS). To gain insights into Ras-C/EBPβ signaling, we investigated C/EBPβ activation by oncogenic Ras. We show that C/EBPβ DNA binding is autorepre...

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Autori principali: Lee, Sook, Shuman, Jon D., Guszczynski, Tad, Sakchaisri, Krisada, Sebastian, Thomas, Copeland, Terry D., Miller, Maria, Cohen, Michael S., Taunton, Jack, Smart, Robert C., Xiao, Zhen, Yu, Li-Rong, Veenstra, Timothy D., Johnson, Peter F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876527/
https://ncbi.nlm.nih.gov/pubmed/20351173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00782-09
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