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Targeted Deletion of Capn4 in Cells of the Chondrocyte Lineage Impairs Chondrocyte Proliferation and Differentiation

Calpains are calcium-dependent intracellular cysteine proteases, which include ubiquitously expressed μ- and m-calpains. Both calpains are heterodimers consisting of a large catalytic subunit and a small regulatory subunit. The calpain small subunit encoded by the gene Capn4 directly binds to the in...

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Bibliographic Details
Main Authors: Kashiwagi, Aki, Schipani, Ernestina, Fein, Mikaela J., Greer, Peter A., Shimada, Masako
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876508/
https://ncbi.nlm.nih.gov/pubmed/20368361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00157-10
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