Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergosterol

The antifungal antibiotic natamycin belongs to the family of polyene antibiotics. Its antifungal activity arises via a specific interaction with ergosterol in the plasma membrane (te Welscher et al., J. Biol. Chem. 283:6393-6401, 2008). However, this activity does not involve disruption of the membr...

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Bibliografiske detaljer
Main Authors: te Welscher, Yvonne Maria, Jones, Lynden, van Leeuwen, Martin Richard, Dijksterhuis, Jan, de Kruijff, Ben, Eitzen, Gary, Breukink, Eefjan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876427/
https://ncbi.nlm.nih.gov/pubmed/20385867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01794-09
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