Low Prevalence of fks1 Hot Spot 1 Mutations in a Worldwide Collection of Candida Strains

We evaluated the prevalence of fks1 hot spot (HS) 1 mutations among 133 Candida strains from six species displaying various caspofungin MIC values (from ≤0.008 to >8 μg/ml). Only 4 (2.9%) strains displayed FKS1 HS1 amino acid substitutions: 1 C. albicans (F641Y) among 32 isolates tested (3.1%), 1...

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Detalhes bibliográficos
Main Authors: Castanheira, Mariana, Woosley, Leah N., Diekema, Daniel J., Messer, Shawn A., Jones, Ronald N., Pfaller, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876398/
https://ncbi.nlm.nih.gov/pubmed/20368396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01711-09
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