Humoral Autoimmunity against the Extracellular Domain of the Neuroendocrine Autoantigen IA-2 Heightens the Risk of Type 1 Diabetes

The objective of this study was to determine whether antigenic determinants localized within the extracellular domain of the neuroendocrine autoantigen tyrosine phosphatase-like protein IA-2 are targets of humoral responses in type 1 diabetes (T1DM). Previous studies indicated that the immunodominan...

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Autors principals: Morran, Michael P., Casu, Anna, Arena, Vincent C., Pietropaolo, Susan, Zhang, Ying-Jian, Satin, Leslie S., Nelson, Patrick, Omenn, Gilbert S., Trucco, Massimo, Becker, Dorothy J., Pietropaolo, Massimo
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875834/
https://ncbi.nlm.nih.gov/pubmed/20382696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1257
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