Repression of Cardiac Phospholamban Gene Expression Is Mediated by Thyroid Hormone Receptor-α1 and Involves Targeted Covalent Histone Modifications

Phospholamban (PLB) is a critical regulator of Ca(2+) cycling in heart muscle cells, and its gene expression is markedly down-regulated by T(3). Nonetheless, little is known about the molecular mechanisms of T(3)-dependent gene silencing in cardiac muscle, and it remains unclear whether thyroid horm...

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Bibliografiske detaljer
Main Authors: Belakavadi, Madesh, Saunders, Jason, Weisleder, Noah, Raghava, Preethi S., Fondell, Joseph D.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875831/
https://ncbi.nlm.nih.gov/pubmed/20392835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1241
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