Estradiol Induction of Spermatogenesis Is Mediated via an Estrogen Receptor-α Mechanism Involving Neuroendocrine Activation of Follicle-Stimulating Hormone Secretion

Both testosterone and its nonaromatizable metabolite dihydrotestosterone (DHT) induce spermatogenesis in gonadotropin-deficient hpg mice. Surprisingly, because aromatization is not required, estradiol (E2) also induces spermatogenesis and increases circulating FSH in hpg mice, but the mechanism rema...

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Detalhes bibliográficos
Main Authors: Allan, Charles M., Couse, John F., Simanainen, Ulla, Spaliviero, Jenny, Jimenez, Mark, Rodriguez, Karina, Korach, Kenneth S., Handelsman, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875821/
https://ncbi.nlm.nih.gov/pubmed/20410197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1477
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