CLINICAL ACTIVITY OF SEQUENTIAL FLAVOPIRIDOL, CYTOSINE ARABINOSIDE, AND MITOXANTRONE FOR ADULTS WITH NEWLY DIAGNOSED, POOR RISK ACUTE MYELOGENOUS LEUKEMIA

Flavopiridol, a cyclin-dependent kinase inhibitor, is cytotoxic to leukemic blasts. In a Phase II study, flavopiridol 50 mg/m(2) was given by 1-hour infusion daily × 3 beginning Day 1 followed by 2 gm/m(2)/72 hr ara-C beginning Day 6 and 40 mg/m(2) mitoxantrone on Day 9 (FLAM) to 45 adults with newl...

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Autori principali: Karp, Judith E., Blackford, Amanda, Smith, B. Douglas, Alino, Katrina, Seung, Amy Hatfield, Bolaños-Meade, Javier, Greer, Jacqueline M., Carraway, Hetty E., Gore, Steven D., Jones, Richard J., Levis, Mark J., McDevitt, Michael A., Doyle, L. Austin, Wright, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875369/
https://ncbi.nlm.nih.gov/pubmed/19962759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2009.11.007
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