A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys

BACKGROUND: Variation at the human μ-opioid receptor has been associated with alcohol abuse. The A118G (N40D) polymorphism in humans is functionally mimicked by the C77G (P26R) polymorphism in rhesus monkeys; both show similar in vitro influences on ligand binding and in vivo correlations with physi...

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Bibliographic Details
Main Authors: Vallender, Eric J., Rüedi-Bettschen, Daniela, Miller, Gregory M., Platt, Donna M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875311/
https://ncbi.nlm.nih.gov/pubmed/20153935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2010.01.005
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