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VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis

VEGF is the key growth factor regulating arterial morphogenesis. However, molecular events involved in this process have not been elucidated. Synectin null mice demonstrate impaired VEGF signaling and a marked reduction in arterial morphogenesis. Here we show that this occurs due to delayed traffick...

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Detalhes bibliográficos
Main Authors: Lanahan, Anthony A., Hermans, Karlien, Claes, Filip, Kerley-Hamilton, Joanna S., Zhuang, Zhen W., Giordano, Frank J., Carmeliet, Peter, Simons, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875289/
https://ncbi.nlm.nih.gov/pubmed/20434959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.02.016
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