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Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer
Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are located within exons 18-21. The -216 single nucleotide polymorphism in the promoter region is...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875208/ https://ncbi.nlm.nih.gov/pubmed/20459863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-37 |
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