Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes

BACKGROUND: Mutant HIV (HIV-Env-Tr712) lacking the cytoplasmic tail of the viral glycoprotein (Env-CT) exhibits a cell-type specific replication phenotype such that replicative spread occurs in some T-cell lines (referred to as permissive cells) but fails to do so in most T-cell lines or in PBMCs (r...

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Main Authors: Emerson, Vanessa, Haller, Claudia, Pfeiffer, Tanya, Fackler, Oliver T, Bosch, Valerie
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875203/
https://ncbi.nlm.nih.gov/pubmed/20459872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-43
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