Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

OBJECTIVE: The mammalian target of rapamycin (mTOR)/p70 S6 kinase 1 (S6K1) pathway is a critical signaling component in the development of obesity-linked insulin resistance and operates a nutrient-sensing negative feedback loop toward the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathway. Wher...

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Autors principals: Houde, Vanessa P., Brûlé, Sophie, Festuccia, William T., Blanchard, Pierre-Gilles, Bellmann, Kerstin, Deshaies, Yves, Marette, André
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874694/
https://ncbi.nlm.nih.gov/pubmed/20299475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1324
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