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Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans

BACKGROUND: Irregular uterine bleeding is the major side effect of, and cause for, discontinuation of long-term progestin-only contraceptives (LTPOCs). The endometria of LTPOC-treated women display abnormally enlarged, fragile blood vessels (BV), decreased endometrial blood flow and oxidative stress...

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Detalhes bibliográficos
Main Authors: Krikun, Graciela, Buhimschi, Irina A, Hickey, Martha, Schatz, Frederick, Buchwalder, Lynn, Lockwood, Charles J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874514/
https://ncbi.nlm.nih.gov/pubmed/20423489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-8
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