Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE

Excessive liver production of ketone bodies is one of many metabolic complications that can arise from diabetes, and in severe untreated cases, it can result in ketoacidosis, coma, and death. Mitochondrial HMG-CoA synthase (HMGCS2), the rate-limiting enzyme in ketogenesis, has been shown to interact...

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Autors principals: Kostiuk, Morris A., Keller, Bernd O., Berthiaume, Luc G.
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2010
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874477/
https://ncbi.nlm.nih.gov/pubmed/20124434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-149765
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