Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart

Maternal obesity in pregnancy predisposes offspring to insulin resistance and associated cardiovascular disease. Here, we used a well-established sheep model to investigate the effects of maternal obesity on cardiac functions. Multiparous ewes were assigned to a control (CON) diet [100% of National...

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Hlavní autoři: Wang, Jingying, Ma, Heng, Tong, Chao, Zhang, Hanying, Lawlis, Gavin B., Li, Yuanda, Zang, Mengwei, Ren, Jun, Nijland, Mark J., Ford, Stephen P., Nathanielsz, Peter W., Li, Ji
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2010
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874473/
https://ncbi.nlm.nih.gov/pubmed/20110268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-142315
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