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Aging, Proteotoxicity, Mitochondria, Glycation, NAD(+) and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox
It is suggested that NAD(+) availability strongly affects cellular aging and organism lifespan: low NAD(+) availability increases intracellular levels of glycolytic triose phosphates (glyceraldehyde-3-phosphate and dihydroxyacetone-phosphate) which, if not further metabolized, decompose spontaneousl...
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Research Foundation
2010
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874395/ https://ncbi.nlm.nih.gov/pubmed/20552048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2010.00010 |
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